diff --git a/.build/cassandra-deps-maven-pom.xml b/.build/cassandra-deps-maven-pom.xml
index 4402a8efd9f1..474c1037d0b1 100644
--- a/.build/cassandra-deps-maven-pom.xml
+++ b/.build/cassandra-deps-maven-pom.xml
@@ -161,6 +161,10 @@
       <groupId>com.github.jbellis</groupId>
       <artifactId>jamm</artifactId>
     </dependency>
+    <dependency>
+      <groupId>tools.profiler</groupId>
+      <artifactId>async-profiler</artifactId>
+    </dependency>
     <dependency>
       <groupId>io.netty</groupId>
       <artifactId>netty-all</artifactId>
diff --git a/.build/parent-maven-pom.xml b/.build/parent-maven-pom.xml
index 5d6ca01a4cf4..c75e2545337b 100644
--- a/.build/parent-maven-pom.xml
+++ b/.build/parent-maven-pom.xml
@@ -40,6 +40,7 @@
     <byteman.version>4.0.20</byteman.version>
     <netty.version>4.1.130.Final</netty.version>
     <ohc.version>0.5.1</ohc.version>
+    <async-profiler.version>4.2</async-profiler.version>
 
     <!-- These are referenced in build.xml, so need to be propagated from there -->
     <asm.version>@asm.version@</asm.version>
@@ -465,6 +466,11 @@
         <artifactId>jamm</artifactId>
         <version>${jamm.version}</version>
       </dependency>
+      <dependency>
+        <groupId>tools.profiler</groupId>
+        <artifactId>async-profiler</artifactId>
+        <version>${async-profiler.version}</version>
+      </dependency>
       <dependency>
         <!-- Test scoped jackson-dataformat-yaml also depends on snakeyaml. For now, these versions are aligned
         but if you happen to bump it here then exclude it in jackson-dataformat-yaml.
diff --git a/CHANGES.txt b/CHANGES.txt
index 94dedc059308..93b223ce5913 100644
--- a/CHANGES.txt
+++ b/CHANGES.txt
@@ -1,4 +1,5 @@
 5.1
+ * Support low-overhead async profiling (CASSANDRA-20854)
  * Add configuration for sorted imports in source files (CASSANDRA-17925)
  * Change the eager reference counting of compression dictionaries to lazy (CASSANDRA-21074)
  * Add cursor based optimized compaction path (CASSANDRA-20918)
diff --git a/NEWS.txt b/NEWS.txt
index f2c18f67624a..724d860ea9bb 100644
--- a/NEWS.txt
+++ b/NEWS.txt
@@ -135,6 +135,7 @@ New features
       CASSANDRA-20102 adds a subset of the SQL99 (binary) string functions: "octet_length" defined on all types 
       and "length" defined on UTF8 strings. See CASSANDRA-20102 for more information.
     - New functions `format_bytes` and `format_time` were added. See CASSANDRA-19546.
+    - It is possible to use Async-profiler for various profiling scenarios. See CASSANDRA-20854.
 
 Upgrading
 ---------
diff --git a/conf/jvm-server.options b/conf/jvm-server.options
index d850592db021..3abb5505830d 100644
--- a/conf/jvm-server.options
+++ b/conf/jvm-server.options
@@ -156,6 +156,13 @@
 # Disable chronicle analytics. See CASSANDRA-19656
 -Dchronicle.analytics.disable=true
 
+# AsyncProfiler Flags
+#-Dcassandra.async_profiler.enabled=true|false
+#-Dcassandra.async_profiler.unsafe_mode=true|false
+# When not set, logs from profiler will be placed under
+# directory behind "cassandra.logdir" property, into "async-profiler" sub-directory
+#-Dcassandra.logdir.async_profiler=/tmp/cassandra-profiling
+
 ### Debug options
 
 # uncomment to enable flight recorder
diff --git a/doc/modules/cassandra/nav.adoc b/doc/modules/cassandra/nav.adoc
index 0ced80090dd4..09fcdd884305 100644
--- a/doc/modules/cassandra/nav.adoc
+++ b/doc/modules/cassandra/nav.adoc
@@ -112,6 +112,7 @@
 **** xref:cassandra:managing/operating/password_validation.adoc[Password validation]
 **** xref:cassandra:managing/operating/role_name_generation.adoc[Role name generation]
 **** xref:cassandra:managing/operating/onboarding-to-accord.adoc[]
+**** xref:cassandra:managing/operating/async-profiler.adoc[]
 *** xref:cassandra:managing/tools/index.adoc[Tools]
 **** xref:cassandra:managing/tools/cqlsh.adoc[cqlsh: the CQL shell]
 **** xref:cassandra:managing/tools/nodetool/nodetool.adoc[nodetool]
diff --git a/doc/modules/cassandra/pages/managing/operating/async-profiler.adoc b/doc/modules/cassandra/pages/managing/operating/async-profiler.adoc
new file mode 100644
index 000000000000..8e0421bc74b8
--- /dev/null
+++ b/doc/modules/cassandra/pages/managing/operating/async-profiler.adoc
@@ -0,0 +1,141 @@
+= Async-profiler
+
+Since https://issues.apache.org/jira/browse/CASSANDRA-20854[CASSANDRA-20854], it is possible to use
+https://github.com/async-profiler/async-profiler[async-profiler] to profile your nodes. Async-profiler is
+shipped with Cassandra, so you do not need to do anything else but start to use it by enabling a property.
+Async-profiler functionality is disabled by default. It can be turned on by setting Cassandra's `cassandra.async_profiler.enabled` property to `true`.
+
+There is a command in `nodetool` called `profile` with these sub-commands:
+
+== start
+
+Basic usage:
+----
+$ nodetool profile start
+----
+
+This will start profiling, by default for 60 seconds. If you want, for example, profile memory allocations for
+5 minutes and save results into a file memory-allocation-5m.html you would do:
+
+----
+$ nodetool profile start -e alloc -d 5m -o memory-allocation-5m.html
+----
+
+There are these events possible to profile:
+
+'cpu', 'alloc', 'lock', 'wall', 'nativemem', 'cache_misses', delimited by comma, defaults to 'cpu'.
+
+There are these output formats possible to specify, via `--format` flag:
+
+'flat', 'traces', 'collapsed', 'flamegraph', 'tree', 'jfr', 'otlp', defaults to 'flamegraph'
+
+== status
+
+You can then inspect the state of profiling by `status` subcommand:
+
+----
+$ nodetool profile status
+Profiling is running for 7 seconds
+----
+
+If you attempt to start another profiling while the current profiling is running, this will not be possible:
+
+----
+$ nodetool profile start -e alloc -d 5m -o memory-allocation-5m.html
+Profiler has already started or there was a failure to start it.
+----
+
+== stop
+
+You can stop the profiling prematurely by `stop` sub-command
+
+----
+$ nodetool profile stop -o memory-allocation-5m.html
+----
+
+After the profiling is finished, either by waiting until it stops on its own or by us explicitly, we have a result file in a results directory on a node. We can inspect what results there are by `list` sub-command:
+
+== list
+
+----
+$ nodetool profile list
+memory-allocation-5m.html
+cpu.html
+----
+
+== fetch
+
+If you have access to a node, you can just go to, by default,
+`logs` directory of Cassandra, into `async-profiler` and obtain a respective file. However, in a scenario when
+you are executing remote profiling (nodetool exection is on a physically different machine from Cassandra node), or you do not have the direct access to remote disk, you need to use `fetch` subcommand, which will sent the content of your result file locally where you can save it to whatever destination you want:
+
+----
+$ nodetool profile fetch cpu.html /tmp/cpu.html
+----
+
+== purge
+
+Of course, more you profile, more disk space the results will occupy. If you have direct access, you can just
+remove the files yourself, however if you do not, you need to use `purge` sub-command which will remove all profiling files:
+
+----
+$ nodetool profile purge
+$ nodetool profile list
+<no output>
+----
+
+== execute
+
+You can also execute arbitrary commands, by `execute` subcommand, like this:
+
+----
+nodetool profile execute meminfo
+Call trace storage:   10244 KB
+  Flight recording:       0 KB
+      Dictionaries:      68 KB
+        Code cache:   11934 KB
+------------------------------
+             Total:   22246 KB
+----
+
+However, to execute arbitrary commands for Async-profiler, we need to enable _unsafe_ async profiling by system property of Cassandra `cassandra.async_profiler.unsafe_mode` set to `true`. You will not be able to do this otherwise.
+
+You can also control where profiling files go via `cassandra.logdir.async_profiler` system property. When not set, by default they will be stored to `cassandra.logdir` + `async-profiler` directory.
+
+== Using a Different Async-Profiler Version
+
+If you need to use a different version of async-profiler (for example, to test a newer version or a custom build), you can replace the JAR file in the classpath.
+
+After building Cassandra, replace the JAR in the build output directory:
+
+----
+$ cp /path/to/your/async-profiler-X.Y.jar build/lib/jars/async-profiler-4.2.jar
+----
+
+Or replace it in the lib directory before building:
+
+----
+$ cp /path/to/your/async-profiler-X.Y.jar lib/async-profiler-4.2.jar
+$ ant clean jar
+----
+
+Then restart Cassandra to use the new version.
+
+=== Compatibility Requirements
+
+The replacement JAR must maintain API compatibility with the original version:
+
+* Must include the `one.profiler.AsyncProfiler` class with compatible methods (`getInstance()`, `execute(String)`)
+* Must contain native libraries for your platform in the correct structure:
+** `linux-x64/libasyncProfiler.so`
+** `linux-arm64/libasyncProfiler.so`
+** `macos/libasyncProfiler.so`
+* Must support the same command syntax and profiling events (cpu, alloc, lock, wall, nativemem, cache-misses)
+
+To verify the replacement worked, check the version after restart:
+
+----
+$ nodetool profile status
+----
+
+If you encounter errors, check the Cassandra logs for async-profiler initialization issues.
\ No newline at end of file
diff --git a/src/java/org/apache/cassandra/config/CassandraRelevantProperties.java b/src/java/org/apache/cassandra/config/CassandraRelevantProperties.java
index ca79ff372772..cf514b7dfce1 100644
--- a/src/java/org/apache/cassandra/config/CassandraRelevantProperties.java
+++ b/src/java/org/apache/cassandra/config/CassandraRelevantProperties.java
@@ -62,6 +62,8 @@ public enum CassandraRelevantProperties
     ALLOW_UNSAFE_REPLACE("cassandra.allow_unsafe_replace"),
     ALLOW_UNSAFE_TRANSIENT_CHANGES("cassandra.allow_unsafe_transient_changes"),
     APPROXIMATE_TIME_PRECISION_MS("cassandra.approximate_time_precision_ms", "2"),
+    ASYNC_PROFILER_ENABLED("cassandra.async_profiler.enabled", "false"),
+    ASYNC_PROFILER_UNSAFE_MODE("cassandra.async_profiler.unsafe_mode", "false"),
     /** 2 ** GENSALT_LOG2_ROUNDS rounds of hashing will be performed. */
     AUTH_BCRYPT_GENSALT_LOG2_ROUNDS("cassandra.auth_bcrypt_gensalt_log2_rounds", "4"),
     /** We expect default values on cache retries and interval to be sufficient for everyone but have this escape hatch just in case. */
diff --git a/src/java/org/apache/cassandra/profiler/AsyncProfilerMBean.java b/src/java/org/apache/cassandra/profiler/AsyncProfilerMBean.java
new file mode 100644
index 000000000000..e9209c51cdfb
--- /dev/null
+++ b/src/java/org/apache/cassandra/profiler/AsyncProfilerMBean.java
@@ -0,0 +1,107 @@
+/*
+ * Licensed to the Apache Software Foundation (ASF) under one
+ * or more contributor license agreements.  See the NOTICE file
+ * distributed with this work for additional information
+ * regarding copyright ownership.  The ASF licenses this file
+ * to you under the Apache License, Version 2.0 (the
+ * "License"); you may not use this file except in compliance
+ * with the License.  You may obtain a copy of the License at
+ *
+ *     http://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+
+package org.apache.cassandra.profiler;
+
+import java.io.IOException;
+import java.util.List;
+import java.util.Map;
+
+import org.apache.cassandra.config.CassandraRelevantProperties;
+import org.apache.cassandra.config.DurationSpec;
+import org.apache.cassandra.service.AsyncProfilerService.AsyncProfilerEvent;
+import org.apache.cassandra.service.AsyncProfilerService.AsyncProfilerFormat;
+
+public interface AsyncProfilerMBean
+{
+    String MBEAN_NAME = "org.apache.cassandra.profiler:type=AsyncProfiler";
+
+    /**
+     * Starts profiling.
+     *
+     * As of now, valid keys to the map area:
+     * <p>
+     *   <ul>
+     *     <li>events - comma separated list of {@link AsyncProfilerEvent}</li>
+     *     <li>outputFormat - one of {@link AsyncProfilerFormat}</li>
+     *     <li>duration - duration of profiling, a string, in human-friendly form, see {@link DurationSpec.IntSecondsBound}</li>
+     *     <li>outputFileName - simple name of a file to save results to, under {@link CassandraRelevantProperties#LOG_DIR}/profiler directory</li>
+     *   </ul>
+     * </p>
+     *
+     * @param parameters     Parameters for start command
+     * @return true if profiling has started, false when not (e.g. when it was started already)
+     */
+    boolean start(Map<String, String> parameters);
+
+    /**
+     * Stops profiling.
+     *
+     * As of now, valid keys to the map are:
+     * <p>
+     *   <ul>
+     *     <li>outputFileName - simple file name where to store profiling result, optional</li>
+     *   </ul>
+     * </p>
+     *
+     * @param parameters     Parameters for stop command
+     * @return true if profiling was stopped
+     */
+    boolean stop(Map<String, String> parameters);
+
+    /**
+     * Executes a command.
+     *
+     * @param command command to execute.
+     * @return execution result
+     */
+    String execute(String command);
+
+    /**
+     * Checks if a profiler is available.
+     *
+     * @return true if async profiling is enabled and profiler is initialized, false otherwise.
+     */
+    boolean isEnabled();
+
+    /**
+     * Removes all profile files from disk.
+     */
+    void purge();
+
+    /**
+     * Returns list of files where profiler was saving results.
+     *
+     * @return list of profiler result files
+     */
+    List<String> list();
+
+    /**
+     * Returns the content of a result file. Use {@link #list()} to get their names.
+     *
+     * @param resultFile file with profiler results
+     * @return content of profiler resuls file, or null, when not found.
+     * @throws IOException not found or other exception occurred
+     */
+    byte[] fetch(String resultFile) throws IOException;
+
+    /**
+     * @return status the profiler is in, as string description, for diagnostic purposes
+     */
+    String status();
+}
diff --git a/src/java/org/apache/cassandra/service/AsyncProfilerService.java b/src/java/org/apache/cassandra/service/AsyncProfilerService.java
new file mode 100644
index 000000000000..be14be1fcf13
--- /dev/null
+++ b/src/java/org/apache/cassandra/service/AsyncProfilerService.java
@@ -0,0 +1,535 @@
+/*
+ * Licensed to the Apache Software Foundation (ASF) under one
+ * or more contributor license agreements.  See the NOTICE file
+ * distributed with this work for additional information
+ * regarding copyright ownership.  The ASF licenses this file
+ * to you under the Apache License, Version 2.0 (the
+ * "License"); you may not use this file except in compliance
+ * with the License.  You may obtain a copy of the License at
+ *
+ *     http://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+
+package org.apache.cassandra.service;
+
+import java.io.IOException;
+import java.nio.file.Files;
+import java.nio.file.NoSuchFileException;
+import java.nio.file.Path;
+import java.util.ArrayList;
+import java.util.Arrays;
+import java.util.EnumSet;
+import java.util.List;
+import java.util.Map;
+import java.util.Set;
+import java.util.concurrent.atomic.AtomicReference;
+import java.util.regex.Pattern;
+import javax.management.StandardMBean;
+
+import com.google.common.annotations.VisibleForTesting;
+import org.slf4j.Logger;
+import org.slf4j.LoggerFactory;
+
+import one.profiler.AsyncProfiler;
+import org.apache.cassandra.config.CassandraRelevantProperties;
+import org.apache.cassandra.config.DatabaseDescriptor;
+import org.apache.cassandra.config.DurationSpec;
+import org.apache.cassandra.exceptions.ConfigurationException;
+import org.apache.cassandra.io.util.File;
+import org.apache.cassandra.profiler.AsyncProfilerMBean;
+import org.apache.cassandra.utils.MBeanWrapper;
+
+import static java.lang.String.format;
+import static java.util.stream.Collectors.toList;
+import static org.apache.cassandra.config.CassandraRelevantProperties.ASYNC_PROFILER_ENABLED;
+import static org.apache.cassandra.config.CassandraRelevantProperties.ASYNC_PROFILER_UNSAFE_MODE;
+import static org.apache.cassandra.config.CassandraRelevantProperties.LOG_DIR;
+
+public class AsyncProfilerService implements AsyncProfilerMBean
+{
+    private static final Logger logger = LoggerFactory.getLogger(AsyncProfilerService.class);
+
+    private static final EnumSet<AsyncProfilerEvent> VALID_EVENTS = EnumSet.allOf(AsyncProfilerEvent.class);
+    private static final EnumSet<AsyncProfilerFormat> VALID_FORMATS = EnumSet.allOf(AsyncProfilerFormat.class);
+    private static final Pattern VALID_FILENAME_REGEX_PATTERN = Pattern.compile("^[a-zA-Z0-9-]*\\.?[a-zA-Z0-9-]*$");
+    private static final int MAX_SAFE_PROFILING_DURATION = 43200; // 12 hours
+    private static final String ASYNC_PROFILER_LOG_DIR = Path.of(LOG_DIR.getString(), "profiler").toAbsolutePath().toString();
+
+    public static final String ASYNC_PROFILER_START_EVENTS_PARAM = "events";
+    public static final String ASYNC_PROFILER_START_OUTPUT_FORMAT_PARAM = "outputFormat";
+    public static final String ASYNC_PROFILER_START_DURATION_PARAM = "duration";
+    public static final String ASYNC_PROFILER_START_OUTPUT_FILE_NAME_PARAM = "outputFileName";
+    public static final Set<String> ASYNC_PROFILER_START_PARAMS = Set.of(ASYNC_PROFILER_START_EVENTS_PARAM,
+                                                                          ASYNC_PROFILER_START_OUTPUT_FORMAT_PARAM,
+                                                                          ASYNC_PROFILER_START_DURATION_PARAM,
+                                                                          ASYNC_PROFILER_START_OUTPUT_FILE_NAME_PARAM);
+
+    public static final String ASYNC_PROFILER_STOP_OUTPUT_FILE_NAME_PARAM = "outputFileName";
+    public static final Set<String> ASYNC_PROFILER_STOP_PARAMS = Set.of(ASYNC_PROFILER_STOP_OUTPUT_FILE_NAME_PARAM);
+
+    private static AsyncProfilerService instance;
+    private static AsyncProfiler asyncProfiler;
+    private final boolean unsafeMode;
+    private static String logDir;
+    private final AtomicReference<File> currentResultFile = new AtomicReference<>();
+    private final StartupChecks.AsyncProfilerKernelParamsCheck kernelParamsCheck;
+
+    @VisibleForTesting
+    public static synchronized AsyncProfilerService instance(String logDir, boolean registerMBean)
+    {
+        return instance(logDir, registerMBean, new StartupChecks.AsyncProfilerKernelParamsCheck());
+    }
+
+    @VisibleForTesting
+    public static synchronized AsyncProfilerService instance(String logDir, boolean registerMBean, StartupChecks.AsyncProfilerKernelParamsCheck kernelParamsCheck)
+    {
+        AsyncProfilerService.logDir = logDir;
+        if (instance == null)
+        {
+            try
+            {
+                instance = new AsyncProfilerService(ASYNC_PROFILER_UNSAFE_MODE.getBoolean(), kernelParamsCheck);
+
+                if (registerMBean)
+                {
+                    MBeanWrapper.instance.registerMBean(new StandardMBean(AsyncProfilerService.instance, AsyncProfilerMBean.class),
+                                                        AsyncProfilerService.MBEAN_NAME,
+                                                        MBeanWrapper.OnException.LOG);
+                }
+
+                try
+                {
+                    maybeCreateProfilesLogDir();
+                }
+                catch (Throwable t)
+                {
+                    throw new ConfigurationException(t.getMessage());
+                }
+
+                if (ASYNC_PROFILER_ENABLED.getBoolean())
+                    asyncProfiler = instance.getProfiler();
+            }
+            catch (Throwable t)
+            {
+                throw new RuntimeException(t);
+            }
+        }
+        return AsyncProfilerService.instance;
+    }
+
+    public static synchronized AsyncProfilerService instance()
+    {
+        if (instance == null)
+            return instance(ASYNC_PROFILER_LOG_DIR, true);
+        else
+            return instance;
+    }
+
+    public AsyncProfilerService(boolean unsafeMode)
+    {
+        this(unsafeMode, null);
+    }
+
+    public AsyncProfilerService(boolean unsafeMode, StartupChecks.AsyncProfilerKernelParamsCheck kernelParamsCheck)
+    {
+        this.unsafeMode = unsafeMode;
+        this.kernelParamsCheck = kernelParamsCheck;
+    }
+
+    public enum AsyncProfilerEvent
+    {
+        cpu("cpu"),
+        alloc("alloc"),
+        lock("lock"),
+        wall("wall"),
+        nativemem("nativemem"),
+        cache_misses("cache-misses");
+
+        private final String name;
+
+        AsyncProfilerEvent(String name)
+        {
+            this.name = name;
+        }
+
+        public String getEvent()
+        {
+            return name;
+        }
+
+        public static String parseEvents(String rawString)
+        {
+            if (rawString == null || rawString.isBlank())
+                throw new IllegalArgumentException("Event can not be null nor blank string.");
+
+            try
+            {
+                List<String> processedEvents = new ArrayList<>();
+                for (String rawEvent : rawString.split(","))
+                    processedEvents.add(AsyncProfilerEvent.valueOf(rawEvent).getEvent());
+
+                return String.join(",", processedEvents);
+            }
+            catch (IllegalArgumentException ex)
+            {
+                throw new IllegalArgumentException(format("Event must be one or a combination of %s", VALID_EVENTS));
+            }
+        }
+    }
+
+    public enum AsyncProfilerFormat
+    {
+        flat, traces, collapsed, flamegraph, tree, jfr;
+
+        public static String parseFormat(String rawFormat)
+        {
+            if (rawFormat == null || rawFormat.isBlank())
+                throw new IllegalArgumentException("Event can not be null nor blank string.");
+
+            try
+            {
+                return AsyncProfilerFormat.valueOf(rawFormat).name();
+            }
+            catch (IllegalArgumentException ex)
+            {
+                throw new IllegalArgumentException(format("Format must be one of %s", VALID_FORMATS));
+            }
+        }
+    }
+
+    @Override
+    public synchronized boolean start(Map<String, String> parameters)
+    {
+        if (isRunning())
+            return false;
+
+        validateStartParameters(parameters);
+
+        try
+        {
+            run(new ThrowingFunction<>()
+            {
+                @Override
+                public Object apply(AsyncProfiler profiler) throws Throwable
+                {
+                    maybeCreateProfilesLogDir();
+                    kernelParamsCheck.execute(null, true);
+
+                    String parsedFormat = AsyncProfilerFormat.parseFormat(parameters.get(ASYNC_PROFILER_START_OUTPUT_FORMAT_PARAM));
+                    String parsedEvents = AsyncProfilerEvent.parseEvents(parameters.get(ASYNC_PROFILER_START_EVENTS_PARAM));
+                    File file = new File(logDir, validateOutputFileName(parameters.get(ASYNC_PROFILER_START_OUTPUT_FILE_NAME_PARAM)));
+
+                    String cmd = format("start,%s,event=%s,timeout=%s,file=%s",
+                                        parsedFormat,
+                                        parsedEvents,
+                                        parseDuration(parameters.get(ASYNC_PROFILER_START_DURATION_PARAM)),
+                                        file);
+
+                    currentResultFile.set(file);
+
+                    String result = profiler.execute(cmd);
+                    logger.info("Started Async-Profiler: result={}, cmd={}", result, cmd);
+
+                    return null;
+                }
+            });
+            return true;
+        }
+        catch (IllegalStateException | IllegalArgumentException ex)
+        {
+            throw ex;
+        }
+        catch (Throwable t)
+        {
+            logger.error("Failed to start Async-Profiler", t);
+            return false;
+        }
+    }
+
+    @Override
+    public synchronized boolean stop(Map<String, String> parameters)
+    {
+        if (!isRunning())
+            return false;
+
+        validateStopParameters(parameters);
+
+        try
+        {
+            run(new ThrowingFunction<>()
+            {
+                @Override
+                public Object apply(AsyncProfiler profiler) throws Throwable
+                {
+                    maybeCreateProfilesLogDir();
+                    File resolvedOutputFile;
+                    String cmd = "stop";
+                    String outputFileName = parameters.get(ASYNC_PROFILER_STOP_OUTPUT_FILE_NAME_PARAM);
+                    if (outputFileName != null)
+                        resolvedOutputFile = new File(logDir, validateOutputFileName(outputFileName));
+                    else
+                        resolvedOutputFile = currentResultFile.get();
+
+                    cmd += ",file=" + resolvedOutputFile.absolutePath();
+
+                    String result = profiler.execute(cmd);
+                    logger.debug("Stopped Async-Profiler: result={}, cmd={}", result, cmd);
+
+                    currentResultFile.set(null);
+
+                    return null;
+                }
+            });
+            return true;
+        }
+        catch (IllegalStateException | IllegalArgumentException e)
+        {
+            throw e;
+        }
+        catch (Throwable e)
+        {
+            logger.error("Failed to stop Async-Profiler", e);
+            return false;
+        }
+    }
+
+    @Override
+    public String execute(String command)
+    {
+        if (!unsafeMode)
+        {
+            throw new SecurityException(String.format("The arbitrary command execution is not permitted " +
+                                                      "with %s MBean. If unsafe command execution is required, " +
+                                                      "start Cassandra with %s property set to true. " +
+                                                      "Rejected command: %s",
+                                                      AsyncProfilerService.MBEAN_NAME,
+                                                      CassandraRelevantProperties.ASYNC_PROFILER_UNSAFE_MODE.getKey(), command));
+        }
+
+        return run(new ThrowingFunction<>()
+        {
+            @Override
+            public String apply(AsyncProfiler profiler) throws Throwable
+            {
+                return profiler.execute(validateCommand(command));
+            }
+        });
+    }
+
+    @Override
+    public List<String> list()
+    {
+        try
+        {
+            maybeCreateProfilesLogDir();
+            return Arrays.stream(new File(logDir).list()).map(File::name).sorted().collect(toList());
+        }
+        catch (Throwable t)
+        {
+            return List.of();
+        }
+    }
+
+    @Override
+    public byte[] fetch(String resultFile) throws IOException
+    {
+        try
+        {
+            if (!Path.of(logDir, resultFile).toAbsolutePath().getParent().equals(Path.of(logDir)))
+            {
+                throw new IllegalArgumentException("Illegal file to fetch: " + resultFile);
+            }
+            maybeCreateProfilesLogDir();
+            return Files.readAllBytes(new File(logDir, resultFile).toPath());
+        }
+        catch (NoSuchFileException t)
+        {
+            logger.error("Result file " + resultFile + " not found or error occurred while returning it.", t);
+            throw t;
+        }
+    }
+
+    @Override
+    public void purge()
+    {
+        maybeCreateProfilesLogDir();
+        new File(logDir).deleteRecursive();
+    }
+
+    @Override
+    public String status()
+    {
+        return run(new ThrowingFunction<>()
+        {
+            @Override
+            public String apply(AsyncProfiler asyncProfiler) throws Throwable
+            {
+                return asyncProfiler.execute("status");
+            }
+        });
+    }
+
+    @Override
+    public synchronized boolean isEnabled()
+    {
+        return instance != null && asyncProfiler != null;
+    }
+
+    public static String validateOutputFileName(String outputFile)
+    {
+        if (outputFile == null || outputFile.trim().isEmpty())
+            throw new IllegalArgumentException("Output file name must not be null or empty.");
+
+        if (!VALID_FILENAME_REGEX_PATTERN.matcher(outputFile).matches())
+            throw new IllegalArgumentException(format("Output file name must match pattern %s.", VALID_FILENAME_REGEX_PATTERN));
+
+        return outputFile;
+    }
+
+    public static String validateCommand(String command)
+    {
+        if (command == null || command.isBlank())
+            throw new IllegalArgumentException("Command can not be null or blank string.");
+
+        return command;
+    }
+
+    /**
+     * @param duration duration of profiling
+     * @return converted string representation of duration to seconds
+     */
+    public static int parseDuration(String duration)
+    {
+        int durationSeconds = new DurationSpec.IntSecondsBound(duration).toSeconds();
+        if (durationSeconds > MAX_SAFE_PROFILING_DURATION)
+            throw new IllegalArgumentException(format("Max profiling duration is %s seconds. If you need longer profiling, use execute command instead.",
+                                                      MAX_SAFE_PROFILING_DURATION));
+        return durationSeconds;
+    }
+
+    private static void maybeCreateProfilesLogDir()
+    {
+        String dir = new File(logDir).toAbsolute().toString();
+
+        if ((DatabaseDescriptor.getCommitLogLocation() != null && dir.startsWith(DatabaseDescriptor.getCommitLogLocation())) ||
+            (DatabaseDescriptor.getAccordJournalDirectory() != null && dir.startsWith(DatabaseDescriptor.getAccordJournalDirectory())) ||
+            dir.startsWith(DatabaseDescriptor.getHintsDirectory().absolutePath()) ||
+            (DatabaseDescriptor.getCDCLogLocation() != null && dir.startsWith(DatabaseDescriptor.getCDCLogLocation())) ||
+            (DatabaseDescriptor.getSavedCachesLocation() != null && dir.startsWith(DatabaseDescriptor.getSavedCachesLocation())))
+        {
+            throw new RuntimeException("You can not store Async-Profiler results into system Cassandra directory.");
+        }
+
+        for (String location : StorageService.instance.getAllDataFileLocations())
+        {
+            if (dir.startsWith(location))
+                throw new RuntimeException("You can not store Async-Profiler results into a data directory of Cassandra.");
+        }
+
+        try
+        {
+            new File(logDir).createDirectoriesIfNotExists();
+        }
+        catch (Throwable t)
+        {
+            throw new RuntimeException("Unable to create directory " + logDir);
+        }
+    }
+
+    private void validateStartParameters(Map<String, String> parameters)
+    {
+        if (!ASYNC_PROFILER_START_PARAMS.equals(parameters.keySet()))
+        {
+            throw new IllegalArgumentException("Wrong parameters passed to start async profiler method. Passed parameters" +
+                                               " should be: " + ASYNC_PROFILER_START_PARAMS);
+        }
+    }
+
+    private void validateStopParameters(Map<String, String> parameters)
+    {
+        if (!ASYNC_PROFILER_STOP_PARAMS.containsAll(parameters.keySet()))
+        {
+            throw new IllegalArgumentException("Wrong parameters passed to stop async profiler method. Passed parameters" +
+                                               " should be: " + ASYNC_PROFILER_STOP_PARAMS);
+        }
+    }
+
+    private boolean isRunning()
+    {
+        if (!isEnabled())
+            return false;
+
+        try
+        {
+            String status = status();
+            return status != null && status.contains("Profiling is running");
+        }
+        catch (Throwable t)
+        {
+            throw new RuntimeException(t);
+        }
+    }
+
+    private <T> T run(ThrowingFunction<AsyncProfiler, T> f)
+    {
+        if (!ASYNC_PROFILER_ENABLED.getBoolean())
+            throw new IllegalStateException("Async Profiler is not enabled. Enable it by setting " + ASYNC_PROFILER_ENABLED.getKey() +
+                                            " property to true.");
+        if (asyncProfiler != null)
+        {
+            try
+            {
+                return f.apply(asyncProfiler);
+            }
+            catch (IllegalStateException | IllegalArgumentException t)
+            {
+                throw t;
+            }
+            catch (Throwable t)
+            {
+                throw new RuntimeException(t);
+            }
+        }
+        else
+            throw new IllegalStateException("Async profiler not available.");
+    }
+
+    public abstract static class ThrowingFunction<A, B>
+    {
+        public abstract B apply(AsyncProfiler a) throws Throwable;
+    }
+
+    private AsyncProfiler getProfiler()
+    {
+        if (!ASYNC_PROFILER_ENABLED.getBoolean())
+            return null;
+
+        if (asyncProfiler != null)
+            return asyncProfiler;
+
+        try
+        {
+            asyncProfiler = AsyncProfiler.getInstance();
+            return asyncProfiler;
+        }
+        catch (Throwable t)
+        {
+            throw new IllegalStateException("Unable to get an instance of Async-Profiler", t);
+        }
+    }
+
+    @VisibleForTesting
+    public static void reset()
+    {
+        if (instance != null)
+            asyncProfiler = null;
+
+        instance = null;
+    }
+}
diff --git a/src/java/org/apache/cassandra/service/CassandraDaemon.java b/src/java/org/apache/cassandra/service/CassandraDaemon.java
index 58f69a179347..67c060511144 100644
--- a/src/java/org/apache/cassandra/service/CassandraDaemon.java
+++ b/src/java/org/apache/cassandra/service/CassandraDaemon.java
@@ -263,6 +263,8 @@ protected void setup()
 
         NativeLibrary.tryMlockall();
 
+        AsyncProfilerService.instance();
+
         Keyspace.setInitialized();
         CommitLog.instance.start();
 
diff --git a/src/java/org/apache/cassandra/service/StartupChecks.java b/src/java/org/apache/cassandra/service/StartupChecks.java
index d5696fda29a2..daf0dc8ebe32 100644
--- a/src/java/org/apache/cassandra/service/StartupChecks.java
+++ b/src/java/org/apache/cassandra/service/StartupChecks.java
@@ -147,6 +147,7 @@ public enum StartupCheckType
                                                                       checkSSTablesFormat,
                                                                       checkSystemKeyspaceState,
                                                                       checkLegacyAuthTables,
+                                                                      checkKernelParamsForAsyncProfiler,
                                                                       new DataResurrectionCheck());
 
     public StartupChecks withDefaultTests()
@@ -757,6 +758,68 @@ public void execute(StartupChecksOptions options) throws StartupException
         }
     };
 
+    public static final StartupCheck checkKernelParamsForAsyncProfiler = new AsyncProfilerKernelParamsCheck();
+
+    public static class AsyncProfilerKernelParamsCheck implements StartupCheck
+    {
+        private static final String MESSAGE = "Async-profiler experience likely affected. Kernel symbols are unavailable due to restrictions. " +
+                                              "Try 'sysctl kernel.perf_event_paranoid=1' and 'sysctl kernel.kptr_restrict=0' or its " +
+                                              "variation on your system to resolve the issue.";
+
+        protected int readPerfEventParanoid()
+        {
+            List<String> lines = FileUtils.readLines(new File("/proc/sys/kernel/perf_event_paranoid"));
+            if (!lines.isEmpty())
+                return Integer.parseInt(lines.get(0));
+            return Integer.MIN_VALUE;
+        }
+
+        protected int readKptrRestrict()
+        {
+            List<String> lines = FileUtils.readLines(new File("/proc/sys/kernel/kptr_restrict"));
+            if (!lines.isEmpty())
+                return Integer.parseInt(lines.get(0));
+            return Integer.MIN_VALUE;
+        }
+
+        public void execute(StartupChecksOptions startupChecksOptions, boolean shouldThrow)
+        {
+            try
+            {
+                if (!CassandraRelevantProperties.ASYNC_PROFILER_ENABLED.getBoolean())
+                    return;
+
+                int perfEventParanoid = readPerfEventParanoid();
+                int kptrRestrict = readKptrRestrict();
+
+                if (perfEventParanoid == Integer.MIN_VALUE || kptrRestrict == Integer.MIN_VALUE)
+                {
+                    logger.debug("Unable to determine values for kernel parameter of " +
+                                 "'kernel.perf_event_paranoid' and 'kernel.kptr_restrict' for Async-profiler. " +
+                                 "Its usability might be limited.");
+                }
+                else if (perfEventParanoid > 1 || kptrRestrict != 0)
+                {
+                    if (shouldThrow)
+                        throw new IllegalStateException(MESSAGE);
+                    else
+                        logger.warn(MESSAGE);
+                }
+            }
+            catch (Throwable t)
+            {
+                if (shouldThrow)
+                    throw t;
+            }
+        }
+
+        @Override
+        public void execute(StartupChecksOptions startupChecksOptions)
+        {
+            execute(startupChecksOptions, false);
+        }
+    }
+
     @VisibleForTesting
     public static Path getReadAheadKBPath(String blockDirectoryPath)
     {
diff --git a/src/java/org/apache/cassandra/service/StorageService.java b/src/java/org/apache/cassandra/service/StorageService.java
index aa2df20b0e35..dc9d9e3f680b 100644
--- a/src/java/org/apache/cassandra/service/StorageService.java
+++ b/src/java/org/apache/cassandra/service/StorageService.java
@@ -3978,6 +3978,17 @@ protected synchronized void drain(boolean isFinalShutdown) throws IOException, I
             if (isFinalShutdown)
                 DiskErrorsHandlerService.get().close();
 
+            try
+            {
+                // stop async profiler on shutdown in case a user
+                // did not stop it beforehand on their own
+                AsyncProfilerService.instance().stop(Map.of());
+            }
+            catch (Throwable t)
+            {
+                logger.error("Failed to stop async profiler.", t);
+            }
+
             try
             {
                 // we are not shutting down ScheduledExecutors#scheduledFastTasks to be still able to progress time
diff --git a/src/java/org/apache/cassandra/tools/NodeProbe.java b/src/java/org/apache/cassandra/tools/NodeProbe.java
index aa98d2218ed5..3a62c80cc084 100644
--- a/src/java/org/apache/cassandra/tools/NodeProbe.java
+++ b/src/java/org/apache/cassandra/tools/NodeProbe.java
@@ -118,7 +118,9 @@
 import org.apache.cassandra.metrics.ThreadPoolMetrics;
 import org.apache.cassandra.net.MessagingService;
 import org.apache.cassandra.net.MessagingServiceMBean;
+import org.apache.cassandra.profiler.AsyncProfilerMBean;
 import org.apache.cassandra.service.ActiveRepairServiceMBean;
+import org.apache.cassandra.service.AsyncProfilerService;
 import org.apache.cassandra.service.AutoRepairService;
 import org.apache.cassandra.service.AutoRepairServiceMBean;
 import org.apache.cassandra.service.CacheService;
@@ -188,6 +190,7 @@ public class NodeProbe implements AutoCloseable
     protected PermissionsCacheMBean pcProxy;
     protected RolesCacheMBean rcProxy;
     protected AutoRepairServiceMBean autoRepairProxy;
+    protected AsyncProfilerMBean asyncProfilerProxy;
     protected GuardrailsMBean grProxy;
     protected volatile Output output;
 
@@ -336,6 +339,9 @@ protected void connect() throws IOException
             name = new ObjectName(AutoRepairService.MBEAN_NAME);
             autoRepairProxy = JMX.newMBeanProxy(mbeanServerConn, name, AutoRepairServiceMBean.class);
 
+            name = new ObjectName(AsyncProfilerService.MBEAN_NAME);
+            asyncProfilerProxy = JMX.newMBeanProxy(mbeanServerConn, name, AsyncProfilerMBean.class);
+
             name = new ObjectName(Guardrails.MBEAN_NAME);
             grProxy = JMX.newMBeanProxy(mbeanServerConn, name, GuardrailsMBean.class);
         }
@@ -1330,6 +1336,11 @@ public AccordOperationsMBean getAccordOperationsProxy()
         return accordProxy;
     }
 
+    public AsyncProfilerMBean getAsyncProfilerProxy()
+    {
+        return asyncProfilerProxy;
+    }
+
     public GossiperMBean getGossProxy()
     {
         return gossProxy;
diff --git a/src/java/org/apache/cassandra/tools/nodetool/AsyncProfileCommandGroup.java b/src/java/org/apache/cassandra/tools/nodetool/AsyncProfileCommandGroup.java
new file mode 100644
index 000000000000..cb0bffce9f75
--- /dev/null
+++ b/src/java/org/apache/cassandra/tools/nodetool/AsyncProfileCommandGroup.java
@@ -0,0 +1,263 @@
+/*
+ * Licensed to the Apache Software Foundation (ASF) under one
+ * or more contributor license agreements.  See the NOTICE file
+ * distributed with this work for additional information
+ * regarding copyright ownership.  The ASF licenses this file
+ * to you under the Apache License, Version 2.0 (the
+ * "License"); you may not use this file except in compliance
+ * with the License.  You may obtain a copy of the License at
+ *
+ *     http://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+
+package org.apache.cassandra.tools.nodetool;
+
+import java.io.IOException;
+import java.nio.file.Files;
+import java.nio.file.NoSuchFileException;
+import java.time.ZoneId;
+import java.time.format.DateTimeFormatter;
+import java.util.List;
+import java.util.Map;
+import java.util.function.Consumer;
+
+import org.apache.cassandra.io.util.File;
+import org.apache.cassandra.profiler.AsyncProfilerMBean;
+import org.apache.cassandra.service.AsyncProfilerService.AsyncProfilerEvent;
+import org.apache.cassandra.service.AsyncProfilerService.AsyncProfilerFormat;
+import org.apache.cassandra.tools.NodeProbe;
+import org.apache.cassandra.utils.FBUtilities;
+import picocli.CommandLine.Command;
+import picocli.CommandLine.Option;
+import picocli.CommandLine.Parameters;
+
+import static java.nio.file.StandardOpenOption.CREATE;
+import static java.nio.file.StandardOpenOption.TRUNCATE_EXISTING;
+import static java.nio.file.StandardOpenOption.WRITE;
+import static java.util.stream.Collectors.joining;
+import static org.apache.cassandra.service.AsyncProfilerService.ASYNC_PROFILER_START_DURATION_PARAM;
+import static org.apache.cassandra.service.AsyncProfilerService.ASYNC_PROFILER_START_EVENTS_PARAM;
+import static org.apache.cassandra.service.AsyncProfilerService.ASYNC_PROFILER_START_OUTPUT_FILE_NAME_PARAM;
+import static org.apache.cassandra.service.AsyncProfilerService.ASYNC_PROFILER_START_OUTPUT_FORMAT_PARAM;
+import static org.apache.cassandra.service.AsyncProfilerService.ASYNC_PROFILER_STOP_OUTPUT_FILE_NAME_PARAM;
+import static org.apache.cassandra.service.AsyncProfilerService.parseDuration;
+import static org.apache.cassandra.service.AsyncProfilerService.validateCommand;
+import static org.apache.cassandra.service.AsyncProfilerService.validateOutputFileName;
+
+@Command(name = "profile", description = "Manage Async-Profiler on a Cassandra process",
+subcommands = {
+AsyncProfileCommandGroup.AsyncProfileStartCommand.class,
+AsyncProfileCommandGroup.AsyncProfileStopCommand.class,
+AsyncProfileCommandGroup.AsyncProfileExecuteCommand.class,
+AsyncProfileCommandGroup.AsyncProfilePurgeCommand.class,
+AsyncProfileCommandGroup.AsyncProfileListCommand.class,
+AsyncProfileCommandGroup.AsyncProfileFetchCommand.class,
+AsyncProfileCommandGroup.AsyncProfileStatusCommand.class
+})
+public class AsyncProfileCommandGroup extends AbstractCommand
+{
+    @Override
+    public void execute(NodeProbe probe)
+    {
+        AbstractCommand cmd = new AsyncProfileStartCommand();
+        cmd.probe(probe);
+        cmd.logger(output);
+        cmd.run();
+    }
+
+    private static void doWithProfiler(NodeProbe probe, Consumer<AsyncProfilerMBean> consumer, boolean requiresEnabledProfiler)
+    {
+        AsyncProfilerMBean profiler = probe.getAsyncProfilerProxy();
+
+        if (requiresEnabledProfiler && !profiler.isEnabled())
+        {
+            probe.output().err.println("Async-profiler native library is not enabled or not possible to load.");
+            System.exit(1);
+        }
+
+        consumer.accept(profiler);
+    }
+
+    private static String getOutputFileName(AsyncProfilerFormat outputFormat)
+    {
+        String filename = DateTimeFormatter.ofPattern("yyyy-MM-dd-HH-mm-ss")
+                                           .withZone(ZoneId.systemDefault()).format(FBUtilities.now());
+
+        if (outputFormat == AsyncProfilerFormat.jfr)
+            filename += ".jfr";
+        else
+            filename += ".html";
+
+        return filename;
+    }
+
+    public static void doWithProfiler(NodeProbe probe, Consumer<AsyncProfilerMBean> consumer)
+    {
+        doWithProfiler(probe, consumer, true);
+    }
+
+    @Command(name = "start", description = "Run Async-Profiler on a Cassandra process")
+    public static class AsyncProfileStartCommand extends AbstractCommand
+    {
+        @Option(names = { "-e", "--event" },
+        description = "Event(s) to profile, one of or combination of 'cpu', 'alloc', " +
+                      "'lock', 'wall', 'nativemem', 'cache_misses', delimited by comma, defaults to 'cpu'")
+        public List<AsyncProfilerEvent> event = List.of(AsyncProfilerEvent.cpu);
+
+        @Option(names = { "-o", "--output" }, description = "File name to save profiling results into, defaults to a " +
+                                                            "file of name 'yyyy-MM-dd-HH-mm-ss.html'")
+        public String filename;
+
+        @Option(names = { "-d", "--duration" }, description = "Duration of profiling, defaults to '60s'. Accepts string values " +
+                                                              "in the form of '5m', '30s' and similar.")
+        public String duration = "60s";
+
+        @Option(names = { "-f", "--format" },
+        description = "Output format, one of 'flat', 'traces', 'collapsed', 'flamegraph', 'tree', 'jfr', defaults to 'flamegraph'")
+        public AsyncProfilerFormat outputFormat = AsyncProfilerFormat.flamegraph;
+
+        @Override
+        public void execute(NodeProbe probe)
+        {
+            // make sure it is valid
+            parseDuration(duration);
+
+            if (filename == null)
+                filename = AsyncProfileCommandGroup.getOutputFileName(outputFormat);
+
+            doWithProfiler(probe, profiler -> {
+                Map<String, String> startParameters = Map.of(ASYNC_PROFILER_START_EVENTS_PARAM, event.stream().map(Enum::name).collect(joining(",")),
+                                                             ASYNC_PROFILER_START_OUTPUT_FORMAT_PARAM, outputFormat.name(),
+                                                             ASYNC_PROFILER_START_DURATION_PARAM, duration,
+                                                             ASYNC_PROFILER_START_OUTPUT_FILE_NAME_PARAM, validateOutputFileName(filename));
+                if (!profiler.start(startParameters))
+                {
+                    output.err.println("Profiler has already started or there was a failure to start it.");
+                    System.exit(1);
+                }
+            });
+        }
+    }
+
+    @Command(name = "stop", description = "Stop Async-Profiler on a Cassandra process")
+    public static class AsyncProfileStopCommand extends AbstractCommand
+    {
+        @Option(names = { "-o", "--output" }, description = "File name to save profiling results into, defaults to a " +
+                                                            "file of name 'yyyy-MM-dd-HH-mm-ss.html'")
+        public String filename;
+
+        @Override
+        public void execute(NodeProbe probe)
+        {
+            doWithProfiler(probe, profiler -> {
+                String file = filename != null ? validateOutputFileName(filename) : null;
+                Map<String, String> stopParameters = file == null ? Map.of() : Map.of(ASYNC_PROFILER_STOP_OUTPUT_FILE_NAME_PARAM, file);
+                if (!profiler.stop(stopParameters))
+                {
+                    output.err.println("Profiler has already stopped or there was a failure to stop it.");
+                    System.exit(1);
+                }
+            });
+        }
+    }
+
+    @Command(name = "execute", description = "Execute an arbitrary command on Async-Profiler on a Cassandra process.")
+    public static class AsyncProfileExecuteCommand extends AbstractCommand
+    {
+        @Parameters(index = "0", description = "Raw command to execute. There has to be 'unsafe' profiler configured " +
+                                               "in Cassandra, driven by cassandra.async_profiler.unsafe_mode property set" +
+                                               " to true, to be able to do this.", arity = "1")
+        public String command;
+
+        @Override
+        public void execute(NodeProbe probe)
+        {
+            doWithProfiler(probe, profiler -> {
+                try
+                {
+                    output.out.print(profiler.execute(validateCommand(command)));
+                }
+                catch (Throwable ex)
+                {
+                    output.err.print(ex.getMessage());
+                    System.exit(1);
+                }
+            });
+        }
+    }
+
+    @Command(name = "purge", description = "Remove all profiling results from node's disk")
+    public static class AsyncProfilePurgeCommand extends AbstractCommand
+    {
+        @Override
+        protected void execute(NodeProbe probe)
+        {
+            doWithProfiler(probe, AsyncProfilerMBean::purge, false);
+        }
+    }
+
+    @Command(name = "list", description = "List profiling result files of a node")
+    public static class AsyncProfileListCommand extends AbstractCommand
+    {
+        @Override
+        protected void execute(NodeProbe probe)
+        {
+            doWithProfiler(probe, profiler -> {
+                for (String resultFile : profiler.list())
+                    output.out.println(resultFile);
+            }, false);
+        }
+    }
+
+    @Command(name = "fetch", description = "Copy profiler result file from a node to a local file")
+    public static class AsyncProfileFetchCommand extends AbstractCommand
+    {
+
+        @Parameters(index = "0", description = "Remote profiler file name", arity = "1")
+        private String remoteFile;
+
+        @Parameters(index = "1", description = "Local file name", arity = "1")
+        private String localFile;
+
+        @Override
+        protected void execute(NodeProbe probe)
+        {
+            doWithProfiler(probe, profiler -> {
+                try
+                {
+                    Files.write(new File(localFile).toPath(), profiler.fetch(remoteFile), CREATE, TRUNCATE_EXISTING, WRITE);
+                }
+                catch (NoSuchFileException e)
+                {
+                    probe.output().err.println("Remote file " + remoteFile + " was not found.");
+                    System.exit(1);
+                }
+                catch (IllegalArgumentException e)
+                {
+                    probe.output().err.println(e.getMessage());
+                    System.exit(1);
+                }
+                catch (IOException e)
+                {
+                    throw new RuntimeException(e);
+                }
+            }, false);
+        }
+    }
+
+    @Command(name = "status", description = "Get status of profiling")
+    public static class AsyncProfileStatusCommand extends AbstractCommand
+    {
+        @Override
+        protected void execute(NodeProbe probe)
+        {
+            doWithProfiler(probe, profiler -> output.out.print(profiler.status()));
+        }
+    }
+}
\ No newline at end of file
diff --git a/src/java/org/apache/cassandra/tools/nodetool/NodetoolCommand.java b/src/java/org/apache/cassandra/tools/nodetool/NodetoolCommand.java
index 98793e2748e3..33292b24831c 100644
--- a/src/java/org/apache/cassandra/tools/nodetool/NodetoolCommand.java
+++ b/src/java/org/apache/cassandra/tools/nodetool/NodetoolCommand.java
@@ -149,6 +149,7 @@
                          NetStats.class,
                          PauseHandoff.class,
                          ProfileLoad.class,
+                         AsyncProfileCommandGroup.class,
                          ProxyHistograms.class,
                          RangeKeySample.class,
                          Rebuild.class,
diff --git a/test/distributed/org/apache/cassandra/distributed/mock/nodetool/InternalNodeProbe.java b/test/distributed/org/apache/cassandra/distributed/mock/nodetool/InternalNodeProbe.java
index 1ab4f843b7fb..62e0dad3ea1d 100644
--- a/test/distributed/org/apache/cassandra/distributed/mock/nodetool/InternalNodeProbe.java
+++ b/test/distributed/org/apache/cassandra/distributed/mock/nodetool/InternalNodeProbe.java
@@ -41,6 +41,7 @@
 import org.apache.cassandra.metrics.CassandraMetricsRegistry;
 import org.apache.cassandra.net.MessagingService;
 import org.apache.cassandra.service.ActiveRepairService;
+import org.apache.cassandra.service.AsyncProfilerService;
 import org.apache.cassandra.service.CacheService;
 import org.apache.cassandra.service.CacheServiceMBean;
 import org.apache.cassandra.service.GCInspector;
@@ -90,6 +91,7 @@ protected void connect()
         arsProxy = ActiveRepairService.instance();
         memProxy = ManagementFactory.getMemoryMXBean();
         runtimeProxy = ManagementFactory.getRuntimeMXBean();
+        asyncProfilerProxy = AsyncProfilerService.instance();
     }
 
     @Override
diff --git a/test/distributed/org/apache/cassandra/distributed/test/AsyncProfilerTest.java b/test/distributed/org/apache/cassandra/distributed/test/AsyncProfilerTest.java
new file mode 100644
index 000000000000..9032effb5fc5
--- /dev/null
+++ b/test/distributed/org/apache/cassandra/distributed/test/AsyncProfilerTest.java
@@ -0,0 +1,198 @@
+/*
+ * Licensed to the Apache Software Foundation (ASF) under one
+ * or more contributor license agreements.  See the NOTICE file
+ * distributed with this work for additional information
+ * regarding copyright ownership.  The ASF licenses this file
+ * to you under the Apache License, Version 2.0 (the
+ * "License"); you may not use this file except in compliance
+ * with the License.  You may obtain a copy of the License at
+ *
+ *     http://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+
+package org.apache.cassandra.distributed.test;
+
+import java.nio.file.StandardOpenOption;
+import java.util.List;
+import java.util.UUID;
+
+import org.junit.Rule;
+import org.junit.Test;
+import org.junit.rules.TemporaryFolder;
+
+import org.apache.cassandra.distributed.Cluster;
+import org.apache.cassandra.distributed.api.Feature;
+import org.apache.cassandra.distributed.api.NodeToolResult;
+import org.apache.cassandra.distributed.shared.Uninterruptibles;
+import org.apache.cassandra.distributed.shared.WithProperties;
+import org.apache.cassandra.io.util.File;
+import org.apache.cassandra.io.util.FileUtils;
+import org.apache.cassandra.service.AsyncProfilerService;
+import org.apache.cassandra.service.StartupChecks;
+
+import static java.util.concurrent.TimeUnit.SECONDS;
+import static org.apache.cassandra.config.CassandraRelevantProperties.ASYNC_PROFILER_ENABLED;
+import static org.junit.Assert.assertFalse;
+import static org.junit.Assert.assertTrue;
+
+public class AsyncProfilerTest extends TestBaseImpl
+{
+    @Rule
+    public TemporaryFolder tmpDir = new TemporaryFolder();
+
+    private Cluster cluster;
+
+    /**
+     * Test-friendly kernel params check that returns valid values without reading from /proc
+     */
+    public static class TestAsyncProfilerKernelParamsCheck extends StartupChecks.AsyncProfilerKernelParamsCheck
+    {
+        @Override
+        protected int readPerfEventParanoid()
+        {
+            return 1; // Valid value (must be <= 1)
+        }
+
+        @Override
+        protected int readKptrRestrict()
+        {
+            return 0; // Valid value (must be == 0)
+        }
+    }
+
+    @Test
+    public void testNodetoolCommands() throws Throwable
+    {
+        File newTmpDir = new File(tmpDir.newFolder());
+
+        try (WithProperties withProperties = new WithProperties()
+                                             .set(ASYNC_PROFILER_ENABLED, true);
+             Cluster cluster = init(builder().withNodes(1).withConfig(c -> c.with(Feature.JMX)).start()))
+        {
+            this.cluster = cluster;
+
+            // start / stop / list
+            assertTrue(status().contains("Profiler is not active"));
+            startAndAssert();
+            Uninterruptibles.sleepUninterruptibly(10, SECONDS);
+            stop();
+
+            // start / stop with file name
+            startAndAssert();
+            Uninterruptibles.sleepUninterruptibly(10, SECONDS);
+            String fileName = UUID.randomUUID().toString();
+            stop(fileName);
+            assertTrue(list().contains(fileName));
+
+            // fetch
+            File destination = new File(newTmpDir, UUID.randomUUID().toString());
+            fetch(fileName, destination.absolutePath());
+            assertTrue(destination.length() != 0);
+
+            // list
+            assertFalse(list().isEmpty());
+            assertTrue(list().contains(fileName));
+
+            // purge
+            purge();
+            assertTrue(list().isEmpty());
+
+            // double start
+            startAndAssert();
+            NodeToolResult secondStart = start();
+            secondStart.asserts().failure();
+            assertTrue(secondStart.getStderr().contains("Profiler has already started"));
+        }
+    }
+
+    @Test
+    public void testListPurgeFetchWorksWithDisabledProfiler() throws Throwable
+    {
+        File newTmpDir = new File(tmpDir.newFolder());
+        try (WithProperties withProperties = new WithProperties().set(ASYNC_PROFILER_ENABLED, false);
+             Cluster cluster = init(builder().withNodes(1).withConfig(c -> c.with(Feature.JMX)).start()))
+        {
+            this.cluster = cluster;
+
+            String fileNameToWriteTo = UUID.randomUUID().toString();
+
+            FileUtils.write(new File(newTmpDir, fileNameToWriteTo), List.of("hello world"), StandardOpenOption.CREATE_NEW);
+
+            // Initialize AsyncProfilerService instance in the cluster node context with the test directory
+            String tmpDirPath = newTmpDir.absolutePath();
+            cluster.get(1).runOnInstance(() -> {
+                AsyncProfilerService.instance(tmpDirPath, true, new TestAsyncProfilerKernelParamsCheck());
+            });
+
+            // fetch
+            String destinationFileName = UUID.randomUUID().toString();
+            File destination = new File(newTmpDir, destinationFileName);
+            fetch(fileNameToWriteTo, destination.absolutePath());
+            assertTrue(destination.length() != 0);
+
+            // list
+            assertFalse(list().isEmpty());
+            assertTrue(list().contains(fileNameToWriteTo));
+
+            // purge
+            purge();
+            assertTrue(list().isEmpty());
+        }
+    }
+
+    private String list()
+    {
+        NodeToolResult result = cluster.get(1).nodetoolResult("profile", "list");
+        result.asserts().success();
+        return result.getStdout();
+    }
+
+    private void stop()
+    {
+        NodeToolResult result = cluster.get(1).nodetoolResult("profile", "stop");
+        result.asserts().success();
+    }
+
+    private void stop(String file)
+    {
+        NodeToolResult result = cluster.get(1).nodetoolResult("profile", "stop", "-o", file);
+        result.asserts().success();
+    }
+
+    private NodeToolResult startAndAssert()
+    {
+        NodeToolResult result = cluster.get(1).nodetoolResult("profile", "start", "-e", "cpu");
+        result.asserts().success();
+        return result;
+    }
+
+    private NodeToolResult start()
+    {
+        return cluster.get(1).nodetoolResult("profile", "start", "-e", "cpu");
+    }
+
+    private String status()
+    {
+        NodeToolResult result = cluster.get(1).nodetoolResult("profile", "status");
+        result.asserts().success();
+        return result.getStdout();
+    }
+
+    private void purge()
+    {
+        NodeToolResult result = cluster.get(1).nodetoolResult("profile", "purge");
+        result.asserts().success();
+    }
+
+    private void fetch(String what, String where)
+    {
+        NodeToolResult result = cluster.get(1).nodetoolResult("profile", "fetch", what, where);
+        result.asserts().success();
+    }
+}
diff --git a/test/resources/nodetool/help/nodetool b/test/resources/nodetool/help/nodetool
index b0301217f647..7597462fa0eb 100644
--- a/test/resources/nodetool/help/nodetool
+++ b/test/resources/nodetool/help/nodetool
@@ -97,6 +97,7 @@ The most commonly used nodetool commands are:
     move                                Move node on the token ring to a new token
     netstats                            Print network information on provided host (connecting node by default)
     pausehandoff                        Pause hints delivery process
+    profile                             Manage Async-Profiler on a Cassandra process
     profileload                         Low footprint profiling of activity for a period of time
     proxyhistograms                     Print statistic histograms for network operations
     rangekeysample                      Shows the sampled keys held across all keyspaces
diff --git a/test/resources/nodetool/help/profile b/test/resources/nodetool/help/profile
new file mode 100644
index 000000000000..3724d5f3e7c7
--- /dev/null
+++ b/test/resources/nodetool/help/profile
@@ -0,0 +1,102 @@
+NAME
+        nodetool profile - Manage Async-Profiler on a Cassandra process
+
+SYNOPSIS
+        nodetool [(-h <host> | --host <host>)] [(-p <port> | --port <port>)]
+                [(-pp | --print-port)] [(-pw <password> | --password <password>)]
+                [(-pwf <passwordFilePath> | --password-file <passwordFilePath>)]
+                [(-u <username> | --username <username>)] profile <command> [<args>]
+
+        nodetool [(-h <host> | --host <host>)] [(-p <port> | --port <port>)]
+                [(-pp | --print-port)] [(-pw <password> | --password <password>)]
+                [(-pwf <passwordFilePath> | --password-file <passwordFilePath>)]
+                [(-u <username> | --username <username>)] profile start
+                [(-d <duration> | --duration <duration>)]
+                [(-e <event> | --event <event>)...]
+                [(-f <outputFormat> | --format <outputFormat>)]
+                [(-o <filename> | --output <filename>)]
+
+        nodetool [(-h <host> | --host <host>)] [(-p <port> | --port <port>)]
+                [(-pp | --print-port)] [(-pw <password> | --password <password>)]
+                [(-pwf <passwordFilePath> | --password-file <passwordFilePath>)]
+                [(-u <username> | --username <username>)] profile stop
+                [(-o <filename> | --output <filename>)]
+
+        nodetool [(-h <host> | --host <host>)] [(-p <port> | --port <port>)]
+                [(-pp | --print-port)] [(-pw <password> | --password <password>)]
+                [(-pwf <passwordFilePath> | --password-file <passwordFilePath>)]
+                [(-u <username> | --username <username>)] profile execute [--] <command>
+
+        nodetool [(-h <host> | --host <host>)] [(-p <port> | --port <port>)]
+                [(-pp | --print-port)] [(-pw <password> | --password <password>)]
+                [(-pwf <passwordFilePath> | --password-file <passwordFilePath>)]
+                [(-u <username> | --username <username>)] profile purge
+
+        nodetool [(-h <host> | --host <host>)] [(-p <port> | --port <port>)]
+                [(-pp | --print-port)] [(-pw <password> | --password <password>)]
+                [(-pwf <passwordFilePath> | --password-file <passwordFilePath>)]
+                [(-u <username> | --username <username>)] profile list
+
+        nodetool [(-h <host> | --host <host>)] [(-p <port> | --port <port>)]
+                [(-pp | --print-port)] [(-pw <password> | --password <password>)]
+                [(-pwf <passwordFilePath> | --password-file <passwordFilePath>)]
+                [(-u <username> | --username <username>)] profile fetch [--]
+                <remoteFile> <localFile>
+
+        nodetool [(-h <host> | --host <host>)] [(-p <port> | --port <port>)]
+                [(-pp | --print-port)] [(-pw <password> | --password <password>)]
+                [(-pwf <passwordFilePath> | --password-file <passwordFilePath>)]
+                [(-u <username> | --username <username>)] profile status
+
+OPTIONS
+        -h <host>, --host <host>
+            Node hostname or ip address
+
+        -p <port>, --port <port>
+            Remote jmx agent port number
+
+        -pp, --print-port
+            Operate in 4.0 mode with hosts disambiguated by port number
+
+        -pw <password>, --password <password>
+            Remote jmx agent password
+
+        -pwf <passwordFilePath>, --password-file <passwordFilePath>
+            Path to the JMX password file
+
+        -u <username>, --username <username>
+            Remote jmx agent username
+
+COMMANDS
+        With no arguments, Display help information
+
+        start
+            Run Async-Profiler on a Cassandra process
+
+            With --event option, Event(s) to profile, one of or combination of 'cpu',
+            'alloc', 'lock', 'wall', 'nativemem', 'cache_misses', delimited by comma,
+            defaults to 'cpu'
+
+            With --output option, File name to save profiling results into, defaults to
+            a file of name 'yyyy-MM-dd-HH-mm-ss.html'
+
+            With --duration option, Duration of profiling, defaults to '60s'. Accepts
+            string values in the form of '5m', '30s' and similar.
+
+            With --format option, Output format, one of 'flat', 'traces', 'collapsed',
+            'flamegraph', 'tree', 'jfr', defaults to 'flamegraph'
+        stop
+            Stop Async-Profiler on a Cassandra process
+
+            With --output option, File name to save profiling results into, defaults to
+            a file of name 'yyyy-MM-dd-HH-mm-ss.html'
+        execute
+            Execute an arbitrary command on Async-Profiler on a Cassandra process.
+        purge
+            Remove all profiling results from node's disk
+        list
+            List profiling result files of a node
+        fetch
+            Copy profiler result file from a node to a local file
+        status
+            Get status of profiling
diff --git a/test/resources/nodetool/help/profile$execute b/test/resources/nodetool/help/profile$execute
new file mode 100644
index 000000000000..b95e75fcb313
--- /dev/null
+++ b/test/resources/nodetool/help/profile$execute
@@ -0,0 +1,38 @@
+NAME
+        nodetool profile execute - Execute an arbitrary command on
+        Async-Profiler on a Cassandra process.
+
+SYNOPSIS
+        nodetool [(-h <host> | --host <host>)] [(-p <port> | --port <port>)]
+                [(-pp | --print-port)] [(-pw <password> | --password <password>)]
+                [(-pwf <passwordFilePath> | --password-file <passwordFilePath>)]
+                [(-u <username> | --username <username>)] profile execute [--] <command>
+
+OPTIONS
+        -h <host>, --host <host>
+            Node hostname or ip address
+
+        -p <port>, --port <port>
+            Remote jmx agent port number
+
+        -pp, --print-port
+            Operate in 4.0 mode with hosts disambiguated by port number
+
+        -pw <password>, --password <password>
+            Remote jmx agent password
+
+        -pwf <passwordFilePath>, --password-file <passwordFilePath>
+            Path to the JMX password file
+
+        -u <username>, --username <username>
+            Remote jmx agent username
+
+        --
+            This option can be used to separate command-line options from the
+            list of argument, (useful when arguments might be mistaken for
+            command-line options
+
+        <command>
+            Raw command to execute. There has to be 'unsafe' profiler
+            configured in Cassandra, driven by cassandra.async_profiler.
+            unsafe_mode property set to true, to be able to do this.
diff --git a/test/resources/nodetool/help/profile$fetch b/test/resources/nodetool/help/profile$fetch
new file mode 100644
index 000000000000..351bac9332be
--- /dev/null
+++ b/test/resources/nodetool/help/profile$fetch
@@ -0,0 +1,40 @@
+NAME
+        nodetool profile fetch - Copy profiler result file from a node to a
+        local file
+
+SYNOPSIS
+        nodetool [(-h <host> | --host <host>)] [(-p <port> | --port <port>)]
+                [(-pp | --print-port)] [(-pw <password> | --password <password>)]
+                [(-pwf <passwordFilePath> | --password-file <passwordFilePath>)]
+                [(-u <username> | --username <username>)] profile fetch [--]
+                <remoteFile> <localFile>
+
+OPTIONS
+        -h <host>, --host <host>
+            Node hostname or ip address
+
+        -p <port>, --port <port>
+            Remote jmx agent port number
+
+        -pp, --print-port
+            Operate in 4.0 mode with hosts disambiguated by port number
+
+        -pw <password>, --password <password>
+            Remote jmx agent password
+
+        -pwf <passwordFilePath>, --password-file <passwordFilePath>
+            Path to the JMX password file
+
+        -u <username>, --username <username>
+            Remote jmx agent username
+
+        --
+            This option can be used to separate command-line options from the
+            list of argument, (useful when arguments might be mistaken for
+            command-line options
+
+        <remoteFile>
+            Remote profiler file name
+
+        <localFile>
+            Local file name
diff --git a/test/resources/nodetool/help/profile$list b/test/resources/nodetool/help/profile$list
new file mode 100644
index 000000000000..46c08f696746
--- /dev/null
+++ b/test/resources/nodetool/help/profile$list
@@ -0,0 +1,27 @@
+NAME
+        nodetool profile list - List profiling result files of a node
+
+SYNOPSIS
+        nodetool [(-h <host> | --host <host>)] [(-p <port> | --port <port>)]
+                [(-pp | --print-port)] [(-pw <password> | --password <password>)]
+                [(-pwf <passwordFilePath> | --password-file <passwordFilePath>)]
+                [(-u <username> | --username <username>)] profile list
+
+OPTIONS
+        -h <host>, --host <host>
+            Node hostname or ip address
+
+        -p <port>, --port <port>
+            Remote jmx agent port number
+
+        -pp, --print-port
+            Operate in 4.0 mode with hosts disambiguated by port number
+
+        -pw <password>, --password <password>
+            Remote jmx agent password
+
+        -pwf <passwordFilePath>, --password-file <passwordFilePath>
+            Path to the JMX password file
+
+        -u <username>, --username <username>
+            Remote jmx agent username
diff --git a/test/resources/nodetool/help/profile$purge b/test/resources/nodetool/help/profile$purge
new file mode 100644
index 000000000000..5afb33fade10
--- /dev/null
+++ b/test/resources/nodetool/help/profile$purge
@@ -0,0 +1,27 @@
+NAME
+        nodetool profile purge - Remove all profiling results from node's disk
+
+SYNOPSIS
+        nodetool [(-h <host> | --host <host>)] [(-p <port> | --port <port>)]
+                [(-pp | --print-port)] [(-pw <password> | --password <password>)]
+                [(-pwf <passwordFilePath> | --password-file <passwordFilePath>)]
+                [(-u <username> | --username <username>)] profile purge
+
+OPTIONS
+        -h <host>, --host <host>
+            Node hostname or ip address
+
+        -p <port>, --port <port>
+            Remote jmx agent port number
+
+        -pp, --print-port
+            Operate in 4.0 mode with hosts disambiguated by port number
+
+        -pw <password>, --password <password>
+            Remote jmx agent password
+
+        -pwf <passwordFilePath>, --password-file <passwordFilePath>
+            Path to the JMX password file
+
+        -u <username>, --username <username>
+            Remote jmx agent username
diff --git a/test/resources/nodetool/help/profile$start b/test/resources/nodetool/help/profile$start
new file mode 100644
index 000000000000..85a4238e56c1
--- /dev/null
+++ b/test/resources/nodetool/help/profile$start
@@ -0,0 +1,48 @@
+NAME
+        nodetool profile start - Run Async-Profiler on a Cassandra process
+
+SYNOPSIS
+        nodetool [(-h <host> | --host <host>)] [(-p <port> | --port <port>)]
+                [(-pp | --print-port)] [(-pw <password> | --password <password>)]
+                [(-pwf <passwordFilePath> | --password-file <passwordFilePath>)]
+                [(-u <username> | --username <username>)] profile start
+                [(-d <duration> | --duration <duration>)]
+                [(-e <event> | --event <event>)...]
+                [(-f <outputFormat> | --format <outputFormat>)]
+                [(-o <filename> | --output <filename>)]
+
+OPTIONS
+        -d <duration>, --duration <duration>
+            Duration of profiling, defaults to '60s'. Accepts string values in
+            the form of '5m', '30s' and similar.
+
+        -e <event>, --event <event>
+            Event(s) to profile, one of or combination of 'cpu', 'alloc',
+            'lock', 'wall', 'nativemem', 'cache_misses', delimited by comma,
+            defaults to 'cpu'
+
+        -f <outputFormat>, --format <outputFormat>
+            Output format, one of 'flat', 'traces', 'collapsed', 'flamegraph',
+            'tree', 'jfr', defaults to 'flamegraph'
+
+        -h <host>, --host <host>
+            Node hostname or ip address
+
+        -o <filename>, --output <filename>
+            File name to save profiling results into, defaults to a file of
+            name 'yyyy-MM-dd-HH-mm-ss.html'
+
+        -p <port>, --port <port>
+            Remote jmx agent port number
+
+        -pp, --print-port
+            Operate in 4.0 mode with hosts disambiguated by port number
+
+        -pw <password>, --password <password>
+            Remote jmx agent password
+
+        -pwf <passwordFilePath>, --password-file <passwordFilePath>
+            Path to the JMX password file
+
+        -u <username>, --username <username>
+            Remote jmx agent username
diff --git a/test/resources/nodetool/help/profile$status b/test/resources/nodetool/help/profile$status
new file mode 100644
index 000000000000..029e47a118c3
--- /dev/null
+++ b/test/resources/nodetool/help/profile$status
@@ -0,0 +1,27 @@
+NAME
+        nodetool profile status - Get status of profiling
+
+SYNOPSIS
+        nodetool [(-h <host> | --host <host>)] [(-p <port> | --port <port>)]
+                [(-pp | --print-port)] [(-pw <password> | --password <password>)]
+                [(-pwf <passwordFilePath> | --password-file <passwordFilePath>)]
+                [(-u <username> | --username <username>)] profile status
+
+OPTIONS
+        -h <host>, --host <host>
+            Node hostname or ip address
+
+        -p <port>, --port <port>
+            Remote jmx agent port number
+
+        -pp, --print-port
+            Operate in 4.0 mode with hosts disambiguated by port number
+
+        -pw <password>, --password <password>
+            Remote jmx agent password
+
+        -pwf <passwordFilePath>, --password-file <passwordFilePath>
+            Path to the JMX password file
+
+        -u <username>, --username <username>
+            Remote jmx agent username
diff --git a/test/resources/nodetool/help/profile$stop b/test/resources/nodetool/help/profile$stop
new file mode 100644
index 000000000000..547490c1df88
--- /dev/null
+++ b/test/resources/nodetool/help/profile$stop
@@ -0,0 +1,32 @@
+NAME
+        nodetool profile stop - Stop Async-Profiler on a Cassandra process
+
+SYNOPSIS
+        nodetool [(-h <host> | --host <host>)] [(-p <port> | --port <port>)]
+                [(-pp | --print-port)] [(-pw <password> | --password <password>)]
+                [(-pwf <passwordFilePath> | --password-file <passwordFilePath>)]
+                [(-u <username> | --username <username>)] profile stop
+                [(-o <filename> | --output <filename>)]
+
+OPTIONS
+        -h <host>, --host <host>
+            Node hostname or ip address
+
+        -o <filename>, --output <filename>
+            File name to save profiling results into, defaults to a file of
+            name 'yyyy-MM-dd-HH-mm-ss.html'
+
+        -p <port>, --port <port>
+            Remote jmx agent port number
+
+        -pp, --print-port
+            Operate in 4.0 mode with hosts disambiguated by port number
+
+        -pw <password>, --password <password>
+            Remote jmx agent password
+
+        -pwf <passwordFilePath>, --password-file <passwordFilePath>
+            Path to the JMX password file
+
+        -u <username>, --username <username>
+            Remote jmx agent username
diff --git a/test/unit/org/apache/cassandra/service/AsyncProfilerServiceTest.java b/test/unit/org/apache/cassandra/service/AsyncProfilerServiceTest.java
new file mode 100644
index 000000000000..fc94a3de267c
--- /dev/null
+++ b/test/unit/org/apache/cassandra/service/AsyncProfilerServiceTest.java
@@ -0,0 +1,315 @@
+/*
+ * Licensed to the Apache Software Foundation (ASF) under one
+ * or more contributor license agreements.  See the NOTICE file
+ * distributed with this work for additional information
+ * regarding copyright ownership.  The ASF licenses this file
+ * to you under the Apache License, Version 2.0 (the
+ * "License"); you may not use this file except in compliance
+ * with the License.  You may obtain a copy of the License at
+ *
+ *     http://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+
+package org.apache.cassandra.service;
+
+import java.util.List;
+import java.util.Map;
+import java.util.Optional;
+import java.util.UUID;
+
+import org.junit.After;
+import org.junit.Before;
+import org.junit.BeforeClass;
+import org.junit.Test;
+
+import org.apache.cassandra.config.DatabaseDescriptor;
+import org.apache.cassandra.distributed.shared.WithProperties;
+import org.apache.cassandra.io.util.File;
+import org.apache.cassandra.io.util.FileUtils;
+
+import static java.lang.String.format;
+import static org.apache.cassandra.config.CassandraRelevantProperties.ASYNC_PROFILER_ENABLED;
+import static org.apache.cassandra.config.CassandraRelevantProperties.ASYNC_PROFILER_UNSAFE_MODE;
+import static org.apache.cassandra.service.AsyncProfilerService.ASYNC_PROFILER_START_DURATION_PARAM;
+import static org.apache.cassandra.service.AsyncProfilerService.ASYNC_PROFILER_START_EVENTS_PARAM;
+import static org.apache.cassandra.service.AsyncProfilerService.ASYNC_PROFILER_START_OUTPUT_FILE_NAME_PARAM;
+import static org.apache.cassandra.service.AsyncProfilerService.ASYNC_PROFILER_START_OUTPUT_FORMAT_PARAM;
+import static org.apache.cassandra.service.AsyncProfilerService.ASYNC_PROFILER_STOP_OUTPUT_FILE_NAME_PARAM;
+import static org.apache.cassandra.service.AsyncProfilerService.AsyncProfilerEvent.cpu;
+import static org.apache.cassandra.service.AsyncProfilerService.AsyncProfilerFormat.flamegraph;
+import static org.assertj.core.api.Assertions.assertThatThrownBy;
+import static org.junit.Assert.assertEquals;
+import static org.junit.Assert.assertFalse;
+import static org.junit.Assert.assertNotNull;
+import static org.junit.Assert.assertTrue;
+
+public class AsyncProfilerServiceTest
+{
+    private static final String testOutputPath = FileUtils.getTempDir().path();
+
+    private AsyncProfilerService profiler;
+    private File testOutputFile;
+
+    /**
+     * Test-friendly kernel params check that returns valid values without reading from /proc
+     */
+    private static class TestAsyncProfilerKernelParamsCheck extends StartupChecks.AsyncProfilerKernelParamsCheck
+    {
+        @Override
+        protected int readPerfEventParanoid()
+        {
+            return 1; // Valid value (must be <= 1)
+        }
+
+        @Override
+        protected int readKptrRestrict()
+        {
+            return 0; // Valid value (must be == 0)
+        }
+    }
+
+    @BeforeClass
+    public static void setUpClass()
+    {
+        DatabaseDescriptor.daemonInitialization();
+    }
+
+    @Before
+    public void setUp()
+    {
+        ASYNC_PROFILER_ENABLED.setBoolean(true);
+        testOutputFile = new File(testOutputPath, UUID.randomUUID().toString());
+    }
+
+    @After
+    public void tearDown()
+    {
+        try
+        {
+            Map<String, String> stopParameters = Map.of(ASYNC_PROFILER_STOP_OUTPUT_FILE_NAME_PARAM, testOutputFile.absolutePath());
+            profiler.stop(stopParameters);
+            testOutputFile.deleteIfExists();
+        }
+        catch (Exception e)
+        {
+            // The only meaningful exception that can surface here is if profiler.start
+            // was not called prior to profiler.stop, we can safely ignore this.
+        }
+
+        profiler = null;
+    }
+
+    private AsyncProfilerService getProfiler()
+    {
+        AsyncProfilerService.reset();
+        return AsyncProfilerService.instance(testOutputPath, false, new TestAsyncProfilerKernelParamsCheck());
+    }
+
+    @Test
+    public void testStartAndStopProfiling() throws Throwable
+    {
+        try (WithProperties properties = new WithProperties().set(ASYNC_PROFILER_UNSAFE_MODE, false))
+        {
+            Map<String, String> startParameters = Map.of(ASYNC_PROFILER_START_EVENTS_PARAM, cpu.name(),
+                                                         ASYNC_PROFILER_START_OUTPUT_FORMAT_PARAM, flamegraph.name(),
+                                                         ASYNC_PROFILER_START_DURATION_PARAM, "10s",
+                                                         ASYNC_PROFILER_START_OUTPUT_FILE_NAME_PARAM, testOutputFile.name());
+
+            Map<String, String> stopParameters = Map.of(ASYNC_PROFILER_STOP_OUTPUT_FILE_NAME_PARAM, testOutputFile.name());
+            AsyncProfilerService profiler = getProfiler();
+            profiler.start(startParameters);
+            Thread.sleep(5000);
+            profiler.stop(stopParameters);
+
+            assertTrue("Output profile file should exist", testOutputFile.exists());
+            assertTrue("Output profile file should not be empty", testOutputFile.length() > 0);
+
+            List<String> list = profiler.list();
+            assertFalse(list.isEmpty());
+
+            Optional<String> resultFile = list.stream().filter(f -> f.equals(testOutputFile.name())).findFirst();
+            assertTrue(resultFile.isPresent());
+            byte[] content = profiler.fetch(resultFile.get());
+            assertNotNull(content);
+
+            assertEquals("Profiler is not active\n", profiler.status());
+        }
+    }
+
+    @Test
+    public void testInvalidParametersThrowsException()
+    {
+        try (WithProperties properties = new WithProperties().set(ASYNC_PROFILER_UNSAFE_MODE, false))
+        {
+            Map<String, String> startParameters = Map.of();
+            assertThatThrownBy(() -> getProfiler().start(startParameters))
+            .isInstanceOf(IllegalArgumentException.class)
+            .hasMessageContaining("Wrong parameters passed to start async profiler method. Passed parameters " +
+                                  "should be:");
+        }
+    }
+
+    @Test
+    public void testInvalidEventThrowsException()
+    {
+        try (WithProperties properties = new WithProperties().set(ASYNC_PROFILER_UNSAFE_MODE, false))
+        {
+            Map<String, String> startParameters = Map.of(ASYNC_PROFILER_START_EVENTS_PARAM, "not_a_real_event",
+                                                         ASYNC_PROFILER_START_OUTPUT_FORMAT_PARAM, "flamegraph",
+                                                         ASYNC_PROFILER_START_DURATION_PARAM, "60s",
+                                                         ASYNC_PROFILER_START_OUTPUT_FILE_NAME_PARAM, testOutputFile.name());
+
+            assertThatThrownBy(() -> getProfiler().start(startParameters))
+            .isInstanceOf(IllegalArgumentException.class)
+            .hasMessageContaining("Event must be one or a combination of [cpu, alloc, lock, wall, nativemem, cache_misses]");
+        }
+    }
+
+    @Test
+    public void testInvalidDurationThrowsException()
+    {
+        try (WithProperties properties = new WithProperties().set(ASYNC_PROFILER_UNSAFE_MODE, false))
+        {
+            Map<String, String> startParameters = Map.of(ASYNC_PROFILER_START_EVENTS_PARAM, cpu.name(),
+                                                         ASYNC_PROFILER_START_OUTPUT_FORMAT_PARAM, flamegraph.name(),
+                                                         ASYNC_PROFILER_START_DURATION_PARAM, "13h",
+                                                         ASYNC_PROFILER_START_OUTPUT_FILE_NAME_PARAM, testOutputFile.name());
+            assertThatThrownBy(() -> getProfiler().start(startParameters))
+            .isInstanceOf(IllegalArgumentException.class)
+            .hasMessageContaining("Max profiling duration is 43200 seconds. If you need longer profiling, use execute command instead");
+        }
+    }
+
+    @Test
+    public void testInvalidFormatThrowsException()
+    {
+        try (WithProperties properties = new WithProperties().set(ASYNC_PROFILER_UNSAFE_MODE, false))
+        {
+            Map<String, String> startParameters = Map.of(ASYNC_PROFILER_START_EVENTS_PARAM, cpu.name(),
+                                                         ASYNC_PROFILER_START_OUTPUT_FORMAT_PARAM, "not_a_real_format",
+                                                         ASYNC_PROFILER_START_DURATION_PARAM, "60s",
+                                                         ASYNC_PROFILER_START_OUTPUT_FILE_NAME_PARAM, testOutputFile.name());
+            assertThatThrownBy(() -> getProfiler().start(startParameters))
+            .isInstanceOf(IllegalArgumentException.class)
+            .hasMessageContaining("Format must be one of [flat, traces, collapsed, flamegraph, tree, jfr]");
+        }
+    }
+
+    @Test
+    public void testInvalidOutputFileNameThrowsException()
+    {
+        try (WithProperties properties = new WithProperties().set(ASYNC_PROFILER_UNSAFE_MODE, false))
+        {
+            Map<String, String> startParameters = Map.of(ASYNC_PROFILER_START_EVENTS_PARAM, cpu.name(),
+                                                         ASYNC_PROFILER_START_OUTPUT_FORMAT_PARAM, flamegraph.name(),
+                                                         ASYNC_PROFILER_START_DURATION_PARAM, "60s",
+                                                         ASYNC_PROFILER_START_OUTPUT_FILE_NAME_PARAM, "| grep test");
+            assertThatThrownBy(() -> getProfiler().start(startParameters))
+            .isInstanceOf(IllegalArgumentException.class)
+            .hasMessageContaining("Output file name must match pattern ^[a-zA-Z0-9-]*\\.?[a-zA-Z0-9-]*$");
+        }
+    }
+
+    @Test
+    public void testInvalidTimeoutThrowsException()
+    {
+        try (WithProperties properties = new WithProperties().set(ASYNC_PROFILER_UNSAFE_MODE, false))
+        {
+            Map<String, String> startParameters = Map.of(ASYNC_PROFILER_START_EVENTS_PARAM, cpu.name(),
+                                                         ASYNC_PROFILER_START_OUTPUT_FORMAT_PARAM, flamegraph.name(),
+                                                         ASYNC_PROFILER_START_DURATION_PARAM, "10abc",
+                                                         ASYNC_PROFILER_START_OUTPUT_FILE_NAME_PARAM, "abc");
+            assertThatThrownBy(() -> {
+                getProfiler().start(startParameters);
+            })
+            .isInstanceOf(IllegalArgumentException.class)
+            .hasMessageContaining("Invalid duration: 10abc Accepted units:[SECONDS, MINUTES, HOURS, DAYS] where case matters and only non-negative values.");
+        }
+    }
+
+    @Test
+    public void testSecondStartNotExecuted()
+    {
+        try (WithProperties properties = new WithProperties().set(ASYNC_PROFILER_UNSAFE_MODE, false))
+        {
+            Map<String, String> startParameters = Map.of(ASYNC_PROFILER_START_EVENTS_PARAM, cpu.name(),
+                                                         ASYNC_PROFILER_START_OUTPUT_FORMAT_PARAM, flamegraph.name(),
+                                                         ASYNC_PROFILER_START_DURATION_PARAM, "60s",
+                                                         ASYNC_PROFILER_START_OUTPUT_FILE_NAME_PARAM, testOutputFile.name());
+            Map<String, String> stopParameters = Map.of(ASYNC_PROFILER_STOP_OUTPUT_FILE_NAME_PARAM, testOutputFile.name());
+
+            AsyncProfilerService profiler = getProfiler();
+            assertTrue(profiler.start(startParameters));
+            assertFalse(profiler.start(startParameters));
+            profiler.stop(stopParameters);
+        }
+    }
+
+    @Test
+    public void testProfilerDisabledThrowsException()
+    {
+        try (WithProperties properties = new WithProperties().set(ASYNC_PROFILER_UNSAFE_MODE, true).set(ASYNC_PROFILER_ENABLED, false))
+        {
+            assertThatThrownBy(() -> {
+                AsyncProfilerService profiler = getProfiler();
+                profiler.status();
+            }).hasMessageContaining("Async Profiler is not enabled. Enable it by setting cassandra.async_profiler.enabled property to true.");
+        }
+    }
+
+    @Test
+    public void testAdvancedModeEnabledSuccess() throws Throwable
+    {
+        try (WithProperties properties = new WithProperties().set(ASYNC_PROFILER_UNSAFE_MODE, true))
+        {
+            AsyncProfilerService profiler = getProfiler();
+
+            profiler.execute("start,event=" + cpu.name() + ",file=" + testOutputFile.absolutePath());
+            Thread.sleep(5000);
+            profiler.execute(format("stop,file=%s", testOutputFile));
+
+            assertTrue("Output profile file for unsafe mode should exist", testOutputFile.exists());
+            assertTrue("Output profile file for unsafe mode should not be empty", testOutputFile.length() > 0);
+        }
+    }
+
+    @Test
+    public void testUnsafeExecute()
+    {
+        try (WithProperties properties = new WithProperties().set(ASYNC_PROFILER_UNSAFE_MODE, true))
+        {
+            getProfiler().execute("foo");
+        }
+    }
+
+    @Test
+    public void testFetchIllegalFile()
+    {
+        assertThatThrownBy(() -> getProfiler().fetch("../abc"))
+        .isInstanceOf(IllegalArgumentException.class)
+        .hasMessage("Illegal file to fetch: ../abc");
+
+        assertThatThrownBy(() -> getProfiler().fetch("/etc/abc"))
+        .isInstanceOf(IllegalArgumentException.class)
+        .hasMessage("Illegal file to fetch: /etc/abc");
+    }
+
+    @Test
+    public void testSafeExecute()
+    {
+        try (WithProperties properties = new WithProperties().set(ASYNC_PROFILER_UNSAFE_MODE, false))
+        {
+            assertThatThrownBy(() -> getProfiler().execute("foo"))
+            .isInstanceOf(SecurityException.class)
+            .hasMessageContaining("The arbitrary command execution is not permitted with org.apache.cassandra.profiler:type=AsyncProfiler " +
+                                  "MBean. If unsafe command execution is required, start Cassandra with " + ASYNC_PROFILER_UNSAFE_MODE.getKey() + ' ' +
+                                  "property set to true. Rejected command: foo");
+        }
+    }
+}