diff --git a/packages/client/src/client/client.ts b/packages/client/src/client/client.ts
index 8d96ba0bc..0c6fc67e5 100644
--- a/packages/client/src/client/client.ts
+++ b/packages/client/src/client/client.ts
@@ -43,6 +43,7 @@ import {
     CompleteResultSchema,
     CreateMessageRequestSchema,
     CreateMessageResultSchema,
+    CreateMessageResultWithToolsSchema,
     CreateTaskResultSchema,
     ElicitRequestSchema,
     ElicitResultSchema,
@@ -458,8 +459,10 @@ export class Client<
                     return taskValidationResult.data;
                 }
 
-                // For non-task requests, validate against CreateMessageResultSchema
-                const validationResult = safeParse(CreateMessageResultSchema, result);
+                // For non-task requests, validate against appropriate schema based on tools presence
+                const hasTools = params.tools || params.toolChoice;
+                const resultSchema = hasTools ? CreateMessageResultWithToolsSchema : CreateMessageResultSchema;
+                const validationResult = safeParse(resultSchema, result);
                 if (!validationResult.success) {
                     const errorMessage =
                         validationResult.error instanceof Error ? validationResult.error.message : String(validationResult.error);
diff --git a/test/integration/test/client/client.test.ts b/test/integration/test/client/client.test.ts
index 5574a2d84..66f38e4cd 100644
--- a/test/integration/test/client/client.test.ts
+++ b/test/integration/test/client/client.test.ts
@@ -4132,3 +4132,129 @@ describe('getSupportedElicitationModes', () => {
         expect(result.supportsUrlMode).toBe(false);
     });
 });
+
+describe('Client sampling validation with tools', () => {
+    test('should validate array content with tool_use when request includes tools', async () => {
+        const server = new Server({ name: 'test server', version: '1.0' }, { capabilities: {} });
+
+        const client = new Client({ name: 'test client', version: '1.0' }, { capabilities: { sampling: { tools: {} } } });
+
+        // Handler returns array content with tool_use - should validate with CreateMessageResultWithToolsSchema
+        client.setRequestHandler(CreateMessageRequestSchema, async () => ({
+            model: 'test-model',
+            role: 'assistant',
+            stopReason: 'toolUse',
+            content: [{ type: 'tool_use', id: 'call_1', name: 'test_tool', input: { arg: 'value' } }]
+        }));
+
+        const [clientTransport, serverTransport] = InMemoryTransport.createLinkedPair();
+        await Promise.all([client.connect(clientTransport), server.connect(serverTransport)]);
+
+        const result = await server.createMessage({
+            messages: [{ role: 'user', content: { type: 'text', text: 'hello' } }],
+            maxTokens: 100,
+            tools: [{ name: 'test_tool', inputSchema: { type: 'object' } }]
+        });
+
+        expect(result.stopReason).toBe('toolUse');
+        expect(Array.isArray(result.content)).toBe(true);
+        expect((result.content as Array<{ type: string }>)[0].type).toBe('tool_use');
+    });
+
+    test('should validate single content when request includes tools', async () => {
+        const server = new Server({ name: 'test server', version: '1.0' }, { capabilities: {} });
+
+        const client = new Client({ name: 'test client', version: '1.0' }, { capabilities: { sampling: { tools: {} } } });
+
+        // Handler returns single content (text) - should still validate with CreateMessageResultWithToolsSchema
+        client.setRequestHandler(CreateMessageRequestSchema, async () => ({
+            model: 'test-model',
+            role: 'assistant',
+            content: { type: 'text', text: 'No tool needed' }
+        }));
+
+        const [clientTransport, serverTransport] = InMemoryTransport.createLinkedPair();
+        await Promise.all([client.connect(clientTransport), server.connect(serverTransport)]);
+
+        const result = await server.createMessage({
+            messages: [{ role: 'user', content: { type: 'text', text: 'hello' } }],
+            maxTokens: 100,
+            tools: [{ name: 'test_tool', inputSchema: { type: 'object' } }]
+        });
+
+        expect((result.content as { type: string }).type).toBe('text');
+    });
+
+    test('should validate single content when request has no tools', async () => {
+        const server = new Server({ name: 'test server', version: '1.0' }, { capabilities: {} });
+
+        const client = new Client({ name: 'test client', version: '1.0' }, { capabilities: { sampling: {} } });
+
+        // Handler returns single content - should validate with CreateMessageResultSchema
+        client.setRequestHandler(CreateMessageRequestSchema, async () => ({
+            model: 'test-model',
+            role: 'assistant',
+            content: { type: 'text', text: 'Response' }
+        }));
+
+        const [clientTransport, serverTransport] = InMemoryTransport.createLinkedPair();
+        await Promise.all([client.connect(clientTransport), server.connect(serverTransport)]);
+
+        const result = await server.createMessage({
+            messages: [{ role: 'user', content: { type: 'text', text: 'hello' } }],
+            maxTokens: 100
+        });
+
+        expect((result.content as { type: string }).type).toBe('text');
+    });
+
+    test('should reject array content when request has no tools', async () => {
+        const server = new Server({ name: 'test server', version: '1.0' }, { capabilities: {} });
+
+        const client = new Client({ name: 'test client', version: '1.0' }, { capabilities: { sampling: {} } });
+
+        // Handler returns array content - should fail validation with CreateMessageResultSchema
+        client.setRequestHandler(CreateMessageRequestSchema, async () => ({
+            model: 'test-model',
+            role: 'assistant',
+            content: [{ type: 'text', text: 'Array response' }]
+        }));
+
+        const [clientTransport, serverTransport] = InMemoryTransport.createLinkedPair();
+        await Promise.all([client.connect(clientTransport), server.connect(serverTransport)]);
+
+        await expect(
+            server.createMessage({
+                messages: [{ role: 'user', content: { type: 'text', text: 'hello' } }],
+                maxTokens: 100
+            })
+        ).rejects.toThrow('Invalid sampling result');
+    });
+
+    test('should validate array content when request includes toolChoice', async () => {
+        const server = new Server({ name: 'test server', version: '1.0' }, { capabilities: {} });
+
+        const client = new Client({ name: 'test client', version: '1.0' }, { capabilities: { sampling: { tools: {} } } });
+
+        // Handler returns array content with tool_use
+        client.setRequestHandler(CreateMessageRequestSchema, async () => ({
+            model: 'test-model',
+            role: 'assistant',
+            stopReason: 'toolUse',
+            content: [{ type: 'tool_use', id: 'call_1', name: 'test_tool', input: {} }]
+        }));
+
+        const [clientTransport, serverTransport] = InMemoryTransport.createLinkedPair();
+        await Promise.all([client.connect(clientTransport), server.connect(serverTransport)]);
+
+        const result = await server.createMessage({
+            messages: [{ role: 'user', content: { type: 'text', text: 'hello' } }],
+            maxTokens: 100,
+            tools: [{ name: 'test_tool', inputSchema: { type: 'object' } }],
+            toolChoice: { mode: 'auto' }
+        });
+
+        expect(result.stopReason).toBe('toolUse');
+        expect(Array.isArray(result.content)).toBe(true);
+    });
+});